CCeMMP Seminar Series – Dr. Elizabeth Kellogg – August 2024
By tracie-pierce
Past SeminarsAugust 13, 2024
CRISPR-associated transposition systems allow guide RNA-directed integration of a single DNA insertion in one orientation at a fixed distance from a programmable target sequence. These transposition systems are highly complex, with multiple components interacting to carry out a highly coordinated sequence of events to select target-sites and subsequently integrate cargo DNA. The Kellogg lab seeks to understand the underlying mechanisms of programmable DNA-insertion by using high-resolution single particle Cryo-EM to characterize the structure of these and related transposition systems.
