Centre Publications

Centre Publications

Membranes under the magnetic lens: A dive into the diverse world of membrane protein structures using cryo-EM

Node(s): Monash University
Published in: Chemical Reviews
Type: Review

Piper SJ, Johnson RM, Wootten D, Sexton PM. Membranes under the magnetic lens: A dive into the diverse world of membrane protein structures using cryo-EM. Chem Rev 122(17):13989–14017, 2022. https://doi.org/10.1021/acs.chemrev.1c00837

Structure of phage λ Redβ177 annealase shows how it anneals DNA strands during single-strand annealing homologous DNA recombination

Node(s): University of Wollongong
Published in: BioRxiv
Type: Research Paper

Newing, T, Brewster JL, Yu H, Johnston NP, Fitschen LJ, Tolun G. Structure of phage λ Redβ177 annealase shows how it anneals DNA strands during single-strand annealing homologous DNA recombination. bioRxiv, 2022. https://doi.org/10.1101/2022.04.09.487726

Secretin amino-terminal structure-activity relationships and complementary mutagenesis at the site of docking to the secretin receptor

Node(s): Monash University
Published in: Molecular Pharmacology
Type: Research Paper

Milburn JE, Harikumar KG, Piper SJ, Raval S, Christopoulos A, Wootten D, Sexton PM, Miller LJ. Secretin amino-terminal structure-activity relationships and complementary mutagenesis at the site of docking to the secretin receptor. Mol Pharmacol 101(6):400-407, 2022. https://doi.org/10.1124/molpharm.122.000502

Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation

Node(s): Monash University
Published in: Nature Communications
Type: Research Paper

Deganutti G, Liang Y-L, Zhang X, Khoshouei M, Clydesdale L, Belousoff MJ, Venugopal H, Truong TT, Glukhova A, Keller AN, Gregory KJ, Leach K, Christopoulos A, Danev R, Reynolds CA, Zhao P, Sexton PM, Wootten D. Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation. Nat Commun 13: 92, 2022. https://doi.org/10.1038/s41467-021-27760-0

Mechanism of transcription modulation by the transcription-repair coupling factor

Node(s): University of Wollongong
Published in: Nucleic Acids Research
Type: Research Paper

Paudel BP, Xu ZQ, Jergic S, Oakley AJ, Sharma N, Brown SHJ, Bouwer JC, Lewis PJ, Dixo NE, van Oijen AM & Ghodke H. Mechanism of transcription modulation by the transcription-repair coupling factor. Nucleic Acids Research, 50(10):5688–5712, 2022. https://doi.org/10.1093/nar/gkac449

Redβ177 annealase structure reveals details of oligomerization and λ Red-mediated homologous DNA recombination

Node(s): University of Wollongong
Published in: Nature Communications
Type: Research Paper

Newing TP, Brewster JL, Fitschen LJ, Bouwer JC, Johnston NP, Yu H, & Tolun G. Redβ177 annealase structure reveals details of oligomerization and λ Red-mediated homologous DNA recombination. Nature Communications 13(1):5649. https://doi.org/10.1038/s41467-022-33090-6

Cholesterol-dependent cytolysins: The outstanding questions

Node(s): University of Melbourne
Published in: IUBMB Life
Type: Review

Johnstone, BA, Joseph, R, Christie, MP, Morton, CJ, McGuiness, C, Walsh, JC, et al. Cholesterol-dependent cytolysins: The outstanding questions. IUBMB Life 74(12): 1169– 1179, 2022. https://doi.org/10.1002/iub.2661

Structures of the interleukin 11 signalling complex reveal dynamics of gp130 extracellular domains and the inhibitory mechanism of a cytokine variant

Node(s): University of Melbourne
Published in: BioRxiv
Type: Research Paper

Metcalfe RD, Hanssen E, Fung KY, Aizel K, Kosasih CC, Zlatic CO, Doughty L, Morton CJ, Leis AP, Parker MW, Gooley PR, Putoczki TL, Griffin MDW. Structures of the interleukin 11 signalling complex reveal dynamics of gp130 extracellular domains and the inhibitory mechanism of a cytokine variant. BioRxiv, 2022. https://doi.org/10.1101/2022.07.21.500383

MeasureIce: accessible on-the-fly measurement of ice thickness in cryo-electron microscopy

Node(s): University of Melbourne
Published in: Communications Biology
Type: Research Paper

Brown, HG, Hanssen, E. MeasureIce: accessible on-the-fly measurement of ice thickness in cryo-electron microscopy. Communications Biology 5, 817 (2022). https://doi.org/10.1038/s42003-022-03698-x

Opportunities and challenges for the development of M1 muscarinic receptor positive allosteric modulators in the treatment for neurocognitive deficits

Node(s): Monash University
Published in: British Journal of Pharmacology
Type: Review

Nguyen HTM, Valant C, van der Westhuizen ET, Langmead CJ, Tobin AB, Sexton PM, Christopoulos A. Opportunities and challenges for the development of M1 muscarinic receptor positive allosteric modulators in the treatment for neurocognitive deficits. Br J Pharmacol 10(4), 2022. https://doi.org/10.1111/bph.15982