Centre Publications
The impact of cryo-EM on determining allosteric modulator-bound structures of G protein-coupled receptors
Zhang L, Mobbs JI, May LT, Glukhova A, Thal DM. The impact of cryo-EM on determining allosteric modulator-bound structures of G protein-coupled receptors. Current Opinion in Structural Biology 79: 102560, 2023. https://doi.org/10.1016/j.sbi.2023.102560
Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics
Vuckovic Z, Wang J, Pham V, Mobbs JI, Belousoff MJ, Bhattarai A, Burger WAC, Thompson G, Yeasmin M, Leach K, van der Westhuizen ET, Khajehali E, Liang Y-L, Glukhova A, Wootten D, Lindsley CW, Tobin AB, Sexton PM, Danev R, Valant C, Miao Y, Christopoulos A, Thal DM. Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics. eLife (in press, April 13 2023; 15-09-2022-RA-eLife-83477).
Molecular mechanisms driving and regulating the AAA+ ATPase VCP/p97, an important therapeutic target for treating cancer, neurological and infectious diseases
Valimehr S, Sethi A, Shukla M, Bhattcharyya S, Kazemi M, Rouiller I. Molecular mechanisms driving and regulating the AAA+ ATPase VCP/p97, an important therapeutic target for treating cancer, neurological and infectious diseases. Biomolecules 13(5): 737, 2023. https://doi.org/10.3390/biom13050737
Structural basis of efficacy-driven ligand selectivity at GPCRs
Powers AS, Pham V, Burger WAC, Thompson G, Laloudakis Y, Barnes NW, Sexton PM, Paul SM, Christopoulos A, Thal DM, Felder CC, Valant C & Dror RO. Structural basis of efficacy-driven ligand selectivity at GPCRs. Nat Chem Biol, 2023 (open access 13 February, 2023). https://doi.org/10.1038/s41589-022-01247-5
Biochemical characterization of caenorhabditis elegans ferritins
Mubarak SSM, Malcolm TR, Brown HG, Hanssen E, Maher MJ, McColl G, and Jameson GNL. Biochemical characterization of caenorhabditis elegans ferritins. Biochemistry 62(9): 1484-1496, 2023. https://doi.org/10.1021/acs.biochem.3c00005
Structural basis for bacterial energy extraction from atmospheric hydrogen
Grinter R, Kropp A, Venugopal H, Senger M, Badley J, Cabotaje PR, Jia R, Duan Z, Huang P, Stripp ST, Barlow CK, Belousoff M, Shafaat HS, Cook GM, Schittenhelm RB, Vincent KA, Khalid S, Berggren G & Greening C. Structural basis for bacterial energy extraction from atmospheric hydrogen. Nature 615: 541–547, 2023. https://doi.org/10.1038/s41586-023-05781-7
Ligands selectively tune the local and global motions of neurotensin receptor 1 (NTS1)
Bumbak F, Pons M, Inoue A, Paniagua JC, Yan F, Wu H, Robson SA, Bathgate R, Scott DJ, Gooley PR, Ziarek JJ. Ligands selectively tune the local and global motions of neurotensin receptor 1 (NTS1). Cell Reports 42(1): 112015, 2023. https://doi.org/10.1016/j.celrep.2023.112015
Structure-based insight into development of selective and non-selective amylin and calcitonin receptor agonists
Cao J, Belousoff MJ, Danev R, Fletcher MM, dal Maso E, Schreuder H, Lorenz K, Evers A, Tiwari G, Besenius B, Li Z, Johnson RM, Wootten D, Sexton PM. Structure-based insight into development of selective and non-selective amylin and calcitonin receptor agonists. (in revision, Nat Chem Biol), 2022. https://doi.org/10.21203/rs.3.rs-2268316/v1
Structural remodeling of Coxiella burnetii during its biphasic developmental cycle revealed by cryo-electron tomography
Kaplan M, Shepherd DC, Vankadari N, Kim KW, Larson CL, Dutka P, Beare PA, Krzymowski E, Heinzen RA, Jensen GJ, Ghosal D. Structural remodeling of Coxiella burnetii during its biphasic developmental cycle revealed by cryo-electron tomography (in revision) bioRxiv, 2022. https://doi.org/10.1101/2022.08.23.505044
Cryo-EM structure of the Agrobacterium tumefaciens type IV secretion system-associated T-pilus reveals stoichiometric protein-phospholipid assembly
Kreida S, Narita A, Johnson MD, Tocheva EI, Das A, Ghosal D, Jensen GJ. Cryo-EM structure of the Agrobacterium tumefaciens type IV secretion system-associated T-pilus reveals stoichiometric protein-phospholipid assembly. Structure, 31(4):P385-394.E4, 2023. https://doi.org/10.1016/j.str.2023.02.005