Centre Publications

Centre Publications

MDTOMO method for continuous conformational variability analysis in cryo electron subtomograms based on molecular dynamics simulations.

Published in: Science Reports
Type: Research Paper

Vuillemot R, Rouiller I, Jonić S. Sci Rep. 2023 Jun 30;13(1):10596. doi: 10.1038/s41598-023-37037-9.

Inhibitory investigations of acyl-CoA derivatives against human lipoxygenase isozymes. I

Published in: International Journal of Molecular Sciences
Type: Research Paper

Tran M, Yang K, Glukhova A, Holinstat M, Holman T. Int J Mol Sci. 2023 Jun 30;24(13):10941. doi: 10.3390/ijms241310941.

Structural characterisation of the complete cycle of sliding clamp loading in Escherichia coli.

Published in: BioRxiv
Type: Research Paper

Xu Z-Q, Jetgic S, Lo ATY, Pradhan AC, Brown SHJ, Bouwer JC, Ghodke H, Lewis PJ, Tolun G, Oakley AJ, Dixon NE (2023). BioRx July 21, 2023 https://doi.org/10.1101/2023.07.20.549978.

Real-time pH-dependent self-assembly of ionisable lipids from COVID-19 vaccines and in situ nucleic acid complexation.

Published in: Angewandte Chemie International Edition
Type: Research Paper

Yu H, Angelova A, Angelov B, Dyett B, Matthews L, Zhang Y, Mohamad ME, Cai X, Valimehr S, Drummond CJ, Zhai J (2023). Angewandte Chemie International Edition, June 30. https://doi.org/10.1002/ange.202304977 .

The impact of cryo-EM on determining allosteric modulator-bound structures of G protein-coupled receptors

Published in: Current Opinion in Structural Biology
Type: Research Paper

Zhang L, Mobbs JI, May LT, Glukhova A, Thal DM. Current Opinion in Structural Biology 79: 102560, 2023. https://doi.org/10.1016/j.sbi.2023.102560

Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics

Published in: eLife
Type: Research Paper

Vuckovic Z, Wang J, Pham V, Mobbs JI, Belousoff MJ, Bhattarai A, Burger WAC, Thompson G, Yeasmin M, Leach K, van der Westhuizen ET, Khajehali E, Liang Y-L, Glukhova A, Wootten D, Lindsley CW, Tobin AB, Sexton PM, Danev R, Valant C, Miao Y, Christopoulos A, Thal DM. Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics. eLife May 30;12:e83477 doi: 10.7554/eLife.83477.

Molecular mechanisms driving and regulating the AAA+ ATPase VCP/p97, an important therapeutic target for treating cancer, neurological and infectious diseases

Published in: Biomolecules
Type: Research Paper

Valimehr S, Sethi A, Shukla M, Bhattcharyya S, Kazemi M, Rouiller I. Molecular mechanisms driving and regulating the AAA+ ATPase VCP/p97, an important therapeutic target for treating cancer, neurological and infectious diseases. Biomolecules 13(5): 737, 2023. https://doi.org/10.3390/biom13050737

Structural basis of efficacy-driven ligand selectivity at GPCRs

Published in: Nature Chemical Biology
Type: Research Paper

Powers AS, Pham V, Burger WAC, Thompson G, Laloudakis Y, Barnes NW, Sexton PM, Paul SM, Christopoulos A, Thal DM, Felder CC, Valant C & Dror RO. Structural basis of efficacy-driven ligand selectivity at GPCRs. Nat Chem Biol, 2023 (open access 13 February, 2023). https://doi.org/10.1038/s41589-022-01247-5

Biochemical characterization of caenorhabditis elegans ferritins

Published in: Biochemistry
Type: Research Paper

Mubarak SSM, Malcolm TR, Brown HG, Hanssen E, Maher MJ, McColl G, and Jameson GNL. Biochemical characterization of caenorhabditis elegans ferritins. Biochemistry 62(9): 1484-1496, 2023. https://doi.org/10.1021/acs.biochem.3c00005

Structural basis for bacterial energy extraction from atmospheric hydrogen

Published in: Nature
Type: Research Paper

Grinter R, Kropp A, Venugopal H, Senger M, Badley J, Cabotaje PR, Jia R, Duan Z, Huang P, Stripp ST, Barlow CK, Belousoff M, Shafaat HS, Cook GM, Schittenhelm RB, Vincent KA, Khalid S, Berggren G & Greening C. Structural basis for bacterial energy extraction from atmospheric hydrogen. Nature 615: 541–547, 2023. https://doi.org/10.1038/s41586-023-05781-7