Centre Publications

Centre Publications

The impact of cryo-EM on determining allosteric modulator-bound structures of G protein-coupled receptors

Published in: Current Opinion in Structural Biology
Type: Research Paper

Zhang L, Mobbs JI, May LT, Glukhova A, Thal DM. The impact of cryo-EM on determining allosteric modulator-bound structures of G protein-coupled receptors. Current Opinion in Structural Biology 79: 102560, 2023. https://doi.org/10.1016/j.sbi.2023.102560

Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics

Published in: eLife
Type: Research Paper

Vuckovic Z, Wang J, Pham V, Mobbs JI, Belousoff MJ, Bhattarai A, Burger WAC, Thompson G, Yeasmin M, Leach K, van der Westhuizen ET, Khajehali E, Liang Y-L, Glukhova A, Wootten D, Lindsley CW, Tobin AB, Sexton PM, Danev R, Valant C, Miao Y, Christopoulos A, Thal DM. Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics. eLife (in press, April 13 2023; 15-09-2022-RA-eLife-83477).

Molecular mechanisms driving and regulating the AAA+ ATPase VCP/p97, an important therapeutic target for treating cancer, neurological and infectious diseases

Published in: Biomolecules
Type: Research Paper

Valimehr S, Sethi A, Shukla M, Bhattcharyya S, Kazemi M, Rouiller I. Molecular mechanisms driving and regulating the AAA+ ATPase VCP/p97, an important therapeutic target for treating cancer, neurological and infectious diseases. Biomolecules 13(5): 737, 2023. https://doi.org/10.3390/biom13050737

Structural basis of efficacy-driven ligand selectivity at GPCRs

Published in: Nature Chemical Biology
Type: Research Paper

Powers AS, Pham V, Burger WAC, Thompson G, Laloudakis Y, Barnes NW, Sexton PM, Paul SM, Christopoulos A, Thal DM, Felder CC, Valant C & Dror RO. Structural basis of efficacy-driven ligand selectivity at GPCRs. Nat Chem Biol, 2023 (open access 13 February, 2023). https://doi.org/10.1038/s41589-022-01247-5

Biochemical characterization of caenorhabditis elegans ferritins

Published in: Biochemistry
Type: Research Paper

Mubarak SSM, Malcolm TR, Brown HG, Hanssen E, Maher MJ, McColl G, and Jameson GNL. Biochemical characterization of caenorhabditis elegans ferritins. Biochemistry 62(9): 1484-1496, 2023. https://doi.org/10.1021/acs.biochem.3c00005

Structural basis for bacterial energy extraction from atmospheric hydrogen

Published in: Nature
Type: Research Paper

Grinter R, Kropp A, Venugopal H, Senger M, Badley J, Cabotaje PR, Jia R, Duan Z, Huang P, Stripp ST, Barlow CK, Belousoff M, Shafaat HS, Cook GM, Schittenhelm RB, Vincent KA, Khalid S, Berggren G & Greening C. Structural basis for bacterial energy extraction from atmospheric hydrogen. Nature 615: 541–547, 2023. https://doi.org/10.1038/s41586-023-05781-7

Ligands selectively tune the local and global motions of neurotensin receptor 1 (NTS1)

Published in: Cell Reports
Type: Research Paper

Bumbak F, Pons M, Inoue A, Paniagua JC, Yan F, Wu H, Robson SA, Bathgate R, Scott DJ, Gooley PR, Ziarek JJ. Ligands selectively tune the local and global motions of neurotensin receptor 1 (NTS1). Cell Reports 42(1): 112015, 2023. https://doi.org/10.1016/j.celrep.2023.112015

Structure-based insight into development of selective and non-selective amylin and calcitonin receptor agonists

Published in: Nature Chemical Biology
Type: Research Paper

Cao J, Belousoff MJ, Danev R, Fletcher MM, dal Maso E, Schreuder H, Lorenz K, Evers A, Tiwari G, Besenius B, Li Z, Johnson RM, Wootten D, Sexton PM. Structure-based insight into development of selective and non-selective amylin and calcitonin receptor agonists. (in revision, Nat Chem Biol), 2022. https://doi.org/10.21203/rs.3.rs-2268316/v1

Structural remodeling of Coxiella burnetii during its biphasic developmental cycle revealed by cryo-electron tomography

Published in: BioRxiv
Type: Research Paper

Kaplan M, Shepherd DC, Vankadari N, Kim KW, Larson CL, Dutka P, Beare PA, Krzymowski E, Heinzen RA, Jensen GJ, Ghosal D. Structural remodeling of Coxiella burnetii during its biphasic developmental cycle revealed by cryo-electron tomography (in revision) bioRxiv, 2022. https://doi.org/10.1101/2022.08.23.505044

Cryo-EM structure of the Agrobacterium tumefaciens type IV secretion system-associated T-pilus reveals stoichiometric protein-phospholipid assembly

Published in: Structure
Type: Research Paper

Kreida S, Narita A, Johnson MD, Tocheva EI, Das A, Ghosal D, Jensen GJ. Cryo-EM structure of the Agrobacterium tumefaciens type IV secretion system-associated T-pilus reveals stoichiometric protein-phospholipid assembly. Structure, 31(4):P385-394.E4, 2023. https://doi.org/10.1016/j.str.2023.02.005