Centre Publications
MDTOMO method for continuous conformational variability analysis in cryo electron subtomograms based on molecular dynamics simulations.
Vuillemot R, Rouiller I, Jonić S. Sci Rep. 2023 Jun 30;13(1):10596. doi: 10.1038/s41598-023-37037-9.
Inhibitory investigations of acyl-CoA derivatives against human lipoxygenase isozymes. I
Tran M, Yang K, Glukhova A, Holinstat M, Holman T. Int J Mol Sci. 2023 Jun 30;24(13):10941. doi: 10.3390/ijms241310941.
Structural characterisation of the complete cycle of sliding clamp loading in Escherichia coli.
Xu Z-Q, Jetgic S, Lo ATY, Pradhan AC, Brown SHJ, Bouwer JC, Ghodke H, Lewis PJ, Tolun G, Oakley AJ, Dixon NE (2023). BioRx July 21, 2023 https://doi.org/10.1101/2023.07.20.549978.
Real-time pH-dependent self-assembly of ionisable lipids from COVID-19 vaccines and in situ nucleic acid complexation.
Yu H, Angelova A, Angelov B, Dyett B, Matthews L, Zhang Y, Mohamad ME, Cai X, Valimehr S, Drummond CJ, Zhai J (2023). Angewandte Chemie International Edition, June 30. https://doi.org/10.1002/ange.202304977 .
The impact of cryo-EM on determining allosteric modulator-bound structures of G protein-coupled receptors
Zhang L, Mobbs JI, May LT, Glukhova A, Thal DM. Current Opinion in Structural Biology 79: 102560, 2023. https://doi.org/10.1016/j.sbi.2023.102560
Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics
Vuckovic Z, Wang J, Pham V, Mobbs JI, Belousoff MJ, Bhattarai A, Burger WAC, Thompson G, Yeasmin M, Leach K, van der Westhuizen ET, Khajehali E, Liang Y-L, Glukhova A, Wootten D, Lindsley CW, Tobin AB, Sexton PM, Danev R, Valant C, Miao Y, Christopoulos A, Thal DM. Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics. eLife May 30;12:e83477 doi: 10.7554/eLife.83477.
Molecular mechanisms driving and regulating the AAA+ ATPase VCP/p97, an important therapeutic target for treating cancer, neurological and infectious diseases
Valimehr S, Sethi A, Shukla M, Bhattcharyya S, Kazemi M, Rouiller I. Molecular mechanisms driving and regulating the AAA+ ATPase VCP/p97, an important therapeutic target for treating cancer, neurological and infectious diseases. Biomolecules 13(5): 737, 2023. https://doi.org/10.3390/biom13050737
Structural basis of efficacy-driven ligand selectivity at GPCRs
Powers AS, Pham V, Burger WAC, Thompson G, Laloudakis Y, Barnes NW, Sexton PM, Paul SM, Christopoulos A, Thal DM, Felder CC, Valant C & Dror RO. Structural basis of efficacy-driven ligand selectivity at GPCRs. Nat Chem Biol, 2023 (open access 13 February, 2023). https://doi.org/10.1038/s41589-022-01247-5
Biochemical characterization of caenorhabditis elegans ferritins
Mubarak SSM, Malcolm TR, Brown HG, Hanssen E, Maher MJ, McColl G, and Jameson GNL. Biochemical characterization of caenorhabditis elegans ferritins. Biochemistry 62(9): 1484-1496, 2023. https://doi.org/10.1021/acs.biochem.3c00005
Structural basis for bacterial energy extraction from atmospheric hydrogen
Grinter R, Kropp A, Venugopal H, Senger M, Badley J, Cabotaje PR, Jia R, Duan Z, Huang P, Stripp ST, Barlow CK, Belousoff M, Shafaat HS, Cook GM, Schittenhelm RB, Vincent KA, Khalid S, Berggren G & Greening C. Structural basis for bacterial energy extraction from atmospheric hydrogen. Nature 615: 541–547, 2023. https://doi.org/10.1038/s41586-023-05781-7