CCeMMP Special Seminar – Dr. Alexey Rak – 21 October 2025

The convergence of advanced biophysics and structural biology has transformed drug discovery, dramatically shortening the path from target to clinical candidate using various modalities. This presentation examines how cryo-EM, AI-driven structure prediction, fragment screening, and high- throughput biophysical methods are being integrated to create powerful new discovery platforms. Case studies will illustrate how these approaches
overcome traditional bottlenecks, enabling rapid identification and optimization of novel therapeutics. These technologies represent not just incremental improvements, but a fundamental paradigm shift in addressing previously intractable disease targets.

Dr. Alexey Rak, Head of the Center of Excellence in Structural Biology &
Biophysics, Sanofi, Paris, France