Cryptic pocket formation underlies allosteric modulatory selectivity at muscarinic GPCRs

Hollingsworth SA, Kelly B, Valant C, Michaelis JA, Mastromihalis O, Thompson G, Venkatakrishnan AJ, Hertig S, Scammells PJ, Sexton PM, Felder CC, Christopoulos A, Dror RO. Cryptic pocket formation underlies allosteric modulatory selectivity at muscarinic GPCRs. Nat Commun 10: 3289, 2019. https://doi.org/10.1038/s41467-019-11062-7