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Discovery of 2-methyl-5-(1H-pyrazol-4-yl)pyridines and related heterocycles as promising M4 mAChR positive allosteric modulators for the treatment of neurocognitive disorders.

Liu B, Thompson G, Manuela J Barnes N, Thal D, Christopoulos A, Capuano B, Valant C, Scammells P. J Med Chem (accepted).