Dominant negative G proteins enhance formation and purification of agonist-GPCR-G protein complexes for structure determination

Liang Y-L, Zhao P, Draper-Joyce CJ, Baltos J, Glukhova A, Troung TT, May LT, Christopoulos A, Wootten D*, Sexton PM*, Furness SGB*. Dominant negative G proteins enhance formation and purification of agonist-GPCR-G protein complexes for structure determination. ACS Pharmacol Transl Sci 1: 12-20, 2018. https://doi.org/10.1021%2Facsptsci.8b00017