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Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation

Deganutti G, Liang Y-L, Zhang X, Khoshouei M, Clydesdale L, Belousoff MJ, Venugopal H, Truong TT, Glukhova A, Keller AN, Gregory KJ, Leach K, Christopoulos A, Danev R, Reynolds CA, Zhao P, Sexton PM, Wootten D. Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation. Nat Commun 13: 92, 2022. https://doi.org/10.1038/s41467-021-27760-0