Isoquinoline small molecule ligands are agonists and probe-dependent allosteric modulators of the glucagon subfamily of GPCRs.

Yuliante E, Trinh PNH, Hick C, Ebenhoch R, Nar H, Weichert D, Christopoulos, A, Sexton PM, Wootten D (2024). Biochem Pharmacol (in press). with industry partner Boehringer Ingelheim. [Preprint SSRN Elsevier (22 May 2024)] https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4831303.