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O-GlcNAc engineering of GPCR peptide-agonists improves their stability and in vivo activity

Levine PM, Balana AT, Sturchler E, Koole C, Noda H, Zarzycka B, Daley EJ, Truong TT, Katritch V, Gardella TJ, Wootten D, Sexton PM, McDonald P, Pratt MR. O-GlcNAc engineering of GPCR peptide-agonists improves their stability and in vivo activity. J Am Chem Soc 141: 14210-14291, 2019. https://doi.org/10.1021/jacs.9b05365