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Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex

Liang Y-L, Khoshouei M, Glukhova A, Furness SGB, Zhao P, Clydesdale L, Koole C, Troung TT, Thal DM, Lei S, Radjainia M, Danev R, Baumeister W, Wang M-W, Miller LJ, Christopoulos A, Sexton PM*, Wootten D*. Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex. Nature 555: 121-125, 2018. https://doi.org/10.1038/nature25773