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Xanomeline displays concomitant orthosteric and allosteric binding modes at the M4 mAChR.

Burger WAC, Pham V, Vuckovic ZA, Powers AS, Mobbs JI, Laloudakis Y, Glukhova A, Wootten D, Tobin AB, Sexton PM, Paul SM, Felder CC, Danev R, Dror RO, Christopoulos A, Valant C, Thal DM (2023). Nature Communications 14(1): 5440. doi: 10.1038/s41467-023-41199-5. With industry collaborators, Karuna.