Centre Publications
Role of conserved tyrosine lid residues in the activation of the M2 muscarinic acetylcholine receptor.
Pham V, Jansen MCCH, Thompson G, Heitman LH, Christopoulos A, Thal DM, Valant C. (2023). Molecular Pharmacology, 104 (3): 92-104. DOI: 10.1124/molpharm.122.000661.
Structural basis of promiscuous substrate transport in organic cation transporter 1.
Zeng YC, Sobti M, Quinn A, Smith NJ, Brown SHJ, Vandenberg JI, Ryan RM, O’Mara ML, Stewart AG. (2023). Nature Communications, 14:6374. doi: 10.1038/s41467-023-42086-9.
The effect of calcium removal from skim milk by ion exchange on the properties of the ultrafiltration retentate.
Wu Q, Ong L, Chen GQ, Varshney S, Hanssen E, Kentish SE, Gras SL (2023). Food Research International 173 (1): 113305. https://www.sciencedirect.com/science/article/pii/S0963996923008505
Molecular and structural insights into the 5-HT2C receptor as a therapeutic target for substance use disorders.
Ubhayarathna M, Langmead CJ, Diepenhorst NA, Stewart GD (2023). British Journal of Pharmacology Sept 7, online ahead of print. doi: 10.1111/bph.16233.
Development of matrix-embedded bovine tracheal organoids to study the innate immune response against bovine respiratory disease.
Quah PS, Tran BM, Corbin VDA, Chang JJ-Y, Wong CY, Diaz-Méndez A, Hartley CA, Zeng W, Hanssen E, Trifunovic Z, Reading PC, Jackson DC, Vinca E, Coin LJM, Deliyannis G (2023). Organoids, 2(2): 82-101. https://doi.org/10.3390/organoids2020007
Cryo-EM structures of human arachidonate 12S-Lipoxygenase (12-LOX) bound to endogenous and exogenous inhibitors.
Mobbs JI, Black KA, Tran M, Burger WAC, Venugopal H, Holman TR, Holinstat M, Thal DM, Glukhova A (2023). Blood 142(14):1233-1242. doi: 10.1182/blood.2023020441. Commentary in Blood, October 5, 2023.
Half a century after their discovery: structural insights into exonuclease and annealase proteins.
Fitschen LJ, Newing TP, Johnston NP, Bell CE, Tolun G (2023). Engineering Microbiology, 100120, https://doi.org/10.1016/j.engmic.2023.100120
A STAT3 protein complex required for mitochondrial mRNA stability and cancer.
Fernando CD, Jayasekara WSN, Inampudi C, Kohonen-Corish MJR, Cooper WA, Beilharz TH, Josephs TM, Garama DFJ, Gough DJ (2023). Cell Reports 42(9):113033. Epub Sept 12, 2023. doi: 10.1016/j.celrep.2023.113033
Structural insight into selectivity of amylin and calcitonin receptor agonists. ,
Cao J, Belousoff MJ, Gerrard E, Danev R, Fletcher MM, Dal Maso E, Schreuder H, Lorenz K, Evers A, Tiwari G, Besenius M, Li Z, Johnson RM, Wootten D, Sexton PM (2023). Nature Chemical Biology, Aug 3, online ahead of print doi: 10.1038/s41589-023-01393-4. With industry partner Sanofi.
Xanomeline displays concomitant orthosteric and allosteric binding modes at the M4 mAChR.
Burger WAC, Pham V, Vuckovic ZA, Powers AS, Mobbs JI, Laloudakis Y, Glukhova A, Wootten D, Tobin AB, Sexton PM, Paul SM, Felder CC, Danev R, Dror RO, Christopoulos A, Valant C, Thal DM (2023). Nature Communications 14(1): 5440. doi: 10.1038/s41467-023-41199-5. With industry collaborators, Karuna.