CCEMMP Seminar Series

The CCeMMP are running a monthly research seminar series for interested researchers, research staff, students and enthusiasts. The seminar will be based mainly around cryo-electron microscopy of/and membrane proteins with a mixture of domestic and international speakers in this field. Speakers will be announced monthly with a calendar invitation with speaker and virtual details.

 

The seminar will be held at 10:00-11:00am AEDT/AEST on every second Tuesday of each month. If you would like to be invited to the seminars, please register to this event and the Centre Manager will send you calendar invitations.

 

Remaining seminar dates for 2021:

  • 9th of November – Prof Radostin Danev (The University of Tokyo)

  • 14th of December – Dr Doreen Matthies (National Institutes of Health)

 

Seminar dates for 2022 will be announced in January 2022.

Past seminars

12 October 2021

Professor Patrick Sexton

Director, ARC Centre for Cryo-electron Microscopy of Membrane Proteins; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University

Using cryo-EM to interrogate the structure and dynamics of GPCRs

G protein-coupled receptors (GPCRs) are the largest superfamily of cell surface receptor proteins and a major target class for drug development. GPCRs are inherently flexible proteins that have evolved to allosterically communicate external signals to modulation of cellular function through recruitment and activation of transducer proteins, particularly G proteins. Technological evolution in cryo-EM combined with continuing advances in biochemical approaches for the stabilisation of active-state complexes of GPCRs with different transducer proteins is now enabling structural interrogation of receptor activation and transducer engagement. Moreover, cryo-EM can access conformational ensembles of GPCR complexes that are present during vitrification, which can provide a window into the dynamics of these complexes.