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Monash University

The Monash Institute of Pharmaceutical Sciences (MIPS) is the research arm of the Faculty of Pharmacy and Pharmaceutical Sciences, Australia’s leading Pharmacy and Pharmaceutical Sciences Program and among the top 3 Institutions in the world for Pharmacy and Pharmacology. MIPS uniquely integrates all aspects of the preclinical drug discovery research pipeline, from target discovery and validation, to medicinal chemistry, drug candidate optimisation and the formulation of drugs for delivery. MIPS houses international leaders in the application of cryo-EM to membrane proteins, with a particular focus on understanding the structure and dynamics of G protein-coupled receptors (GPCRs), the largest family of cell surface receptors and a major target class for therapeutic drug development. There are over 800 GPCRs in the human genome including hundreds of receptors of potential therapeutic interest. MIPS researchers have extensive links to both cryo-EM technology leaders and the pharmaceutical industry.

Monash University

Research focus areas

This node provides the following research opportunities:

Cell Surface Receptors (G protein-coupled receptors)

Node(s): The Walter and Eliza Hall Institute University of Wollongong Monash University

In line with the advanced technical training that is a core feature of the Doctoral training program, we are exploring way to advance each of the 3 key areas in the workflow for cryo-EM of GPCRs from enabling biochemistry, to efficiency and robustness of vitrification and imaging, through to optimised data processing and the ability to directly derive 3D conformational dynamics.

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