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University of Wollongong

Molecular Horizons is a new molecular life sciences institute at the University of Wollongong. As a home to the Wollongong node of the CCeMMP, it houses world-class research in structural biology, molecular biophysics, and cell biology. The facility support team consists of researchers with experience in the entire cryo-EM workflow, from sample preparation to computational analysis. The CCeMMP research at Molecular Horizons, in collaboration with the adjacent Illawarra Health and Medical Research Institute (IHMRI), focuses on the structural study of a number of channels involved in pain regulation and understanding the relationship between structural information to functional behaviour.

Research focus areas

This node provides the following research opportunities:

Cell Surface Receptors (G protein-coupled receptors)

Node(s): The Walter and Eliza Hall Institute University of Wollongong Monash University

In line with the advanced technical training that is a core feature of the Doctoral training program, we are exploring way to advance each of the 3 key areas in the workflow for cryo-EM of GPCRs from enabling biochemistry, to efficiency and robustness of vitrification and imaging, through to optimised data processing and the ability to directly derive 3D conformational dynamics.

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